Plant Derivative May Reduce Resistance To Breast Cancer Drug


Plant derivative may reduce resistance to breast cancer drug A recent study has found that combining tamoxifen, the most prescribed breast cancer drug in the world, with a compound originating from the feverfew plant may help prevent initial or future resistance to the medication.

"A solution to tamoxifen resistance is sorely needed, and if a strategy like this can work, it would make a difference in our clinical care of breast cancer," said Robert Clarke, the study’s lead investigator.

Approximately 70 percent of newly diagnosed breast cancer patients are prescribed tamoxifen, although half of those individuals do not initially respond to the drug due to an aggressive resistance.

In the study, researchers from the Georgetown University Medical Center found that the purified chemical known as parthenolide, a derivative of feverfew, was able to successfully block the activity of nuclear factor kappa B (NF- κB), a protein complex that is often over-expressed in breast cancer patients, leading to the body’s resistance to tamoxifen.

Although the researchers are optimistic, they believe that it is too early to recommend the drug combination to patients as they are still unsure of its long-term benefits.

Personal Liberty

Special To Personal Liberty

You Sound Off! is written by our readers and appears the last Wednesday of each month. If you would like to submit an article or letter to the editor for consideration for You Sound Off!, send it to by the Friday before the last Wednesday of the month. To be considered, a submission should be 750 words or less and must include the writer's name, address and a telephone number. Only the writer's name will be published. Anonymous submissions will not be considered.

Join the Discussion

Comment Policy: We encourage an open discussion with a wide range of viewpoints, even extreme ones, but we will not tolerate racism, profanity or slanderous comments toward the author(s) or comment participants. Make your case passionately, but civilly. Please don't stoop to name calling. We use filters for spam protection. If your comment does not appear, it is likely because it violates the above policy or contains links or language typical of spam. We reserve the right to remove comments at our discretion.