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Plant Derivative May Reduce Resistance To Breast Cancer Drug

March 1, 2010 by  

Plant derivative may reduce resistance to breast cancer drug A recent study has found that combining tamoxifen, the most prescribed breast cancer drug in the world, with a compound originating from the feverfew plant may help prevent initial or future resistance to the medication.

"A solution to tamoxifen resistance is sorely needed, and if a strategy like this can work, it would make a difference in our clinical care of breast cancer," said Robert Clarke, the study’s lead investigator.

Approximately 70 percent of newly diagnosed breast cancer patients are prescribed tamoxifen, although half of those individuals do not initially respond to the drug due to an aggressive resistance.

In the study, researchers from the Georgetown University Medical Center found that the purified chemical known as parthenolide, a derivative of feverfew, was able to successfully block the activity of nuclear factor kappa B (NF- κB), a protein complex that is often over-expressed in breast cancer patients, leading to the body’s resistance to tamoxifen.

Although the researchers are optimistic, they believe that it is too early to recommend the drug combination to patients as they are still unsure of its long-term benefits.

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  • Phil

    A plant that helps fight disease ?… The goverment better ban it quick and start throwing anyone that has this evil devil plant in prison…

  • M French

    Cancer will never be cured as long as the researchers continue to test on a cell line that no longer resembles a human cancer cell. Read an expose by a former researcher, Dermer, stating that a cell line that never dies in a petrie dish has been developed to save researchers expense for constant replacement of dying cell lines. These “immortal cell lines” never die in a petrie dish. Why? Their entire chromosomal and genetic makeup has been altered to survive indefinitely for testing. They therefore no longer resemble human cancer cells. When researchers discover drugs that kill the immortal cells, they don’t work on humans. Enough said – Read “the Immortal Cell” by Dermer – a real shocker. This is why I never contribute to cancer research. All researchers are after today is millions in grants – a continuous money flow into their pockets. Outrageous.

    • s c

      M French, many Americans are still in awe of those who graduate from medical school and eventually begin their practice. As long as American medical schols are tools of Big Pharma (and AMA indifference and arrogance), Americans will never get the quality care they deserve when it comes to a catastrophic disease like cancer.
      The sad fact is that in this once great nation, MONEY is more important than lives. It has been suspected for years, and anyone who doubts it now has chosen to be a part of this disgraceful problem.
      Please buy or borrow a new book called FDA: Fraud, Deception, Abuse. It is an eye-opener for those who hold MDs in high regard. It also dares to include documentation regarding how and why Medicare makes health care worse via ‘legalized’ overbilling, over-priced drugs and stifled innovation. It does not hold Congress as accountable as it should be, but the rest of the book will hammer the remaining nails in the FDA’s coffin. Bury it. Kill it. Get rid of it. The FDA is worse than any cancer.


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