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Genetic Discovery May Pave Way For Better Asthma Treatments

September 8, 2010 by  

Genetic Discovery May Pave Way For Better Asthma Treatments There are no effective treatments for allergic asthma at the moment, so people suffering from this condition can only be treated symptomatically in order to keep their quality of life from deteriorating. However, a new study from Cincinnati Children’s Hospital Medical Center offers hope for better therapeutic strategies in the future.

The center’s scientists have identified a genetic mechanism that can help determine the severity of allergic asthma. They say that what distinguishes a mild form of the disease from a more severe case is the pro-inflammatory protein called interleukin-17 (IL-17A).

When exposed to an environmental pollutant — such as cigarette smoke — the body produces high levels of IL-17A, which in turn stimulates the expression of a gene called complement factor 3 (C3) that sets off an “amplification loop,” perpetuating increasing inflammatory responses.

“This study suggests that at some point it may be possible to treat or prevent severe forms of asthma by inhibiting pathways that drive the production of IL-17A,” said senior investigator Marsha Wills-Karp, director of the Division of Immunobiology at Cincinnati Children’s.

According to the Centers for Disease Control and Prevention, more than 7 percent of adults and more than 9 percent of children in the U.S. have asthma.

The results were presented in the Aug. 29 issue of Nature Immunology.
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  • Ken Roberts

    I hope there will be a help for COPD patients. Seems like the older folks die of that more and more . Short of a lung transplant there is not much help now .

    • http://personalliberty Nancy

      I have family members that suffer from chronic bronchitis
      and copd.Hope they find something to help

  • dan az

    I found that just getting out of the cities helped my wife she hasnt had an attack in years.With all the cars that put out cynide gas from their catalitic converters no wonder there are so much lung problems and you cant blame the industry because they left with nafta.

  • Victor Martens

    “Short of a lung transplant” – that did it, Ken: I live far away, am not american but read your comments. You have exellent autors with help for Asthma and emphysema. Get these booklets – easy for you – and take a reading about hydrogen Peroxide (food grade, diluted), they tell in detail and dozens of other health bits:
    “Hydrogen Peroxide” by William Campbell Douglass MD and a small booklet by Conrad LeBeau. Few inhalations of a spray releaved a joung lady from asthma attacks, at least a few weeks, another with one inhalation only releaved from strong bronquitis. It really works, no “lung transplants”. (Sorry for my english, spanish is better.)

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